生体分子化学研究室（野瀬研究室）のページ
Laboratory of Biomolecular Chemistry
業績ACHIEVEMENT
論文/Publication
Stepwise LCST-Type Phase Separation in Mixtures of Short-Chain Elastin-Like Peptides With Minimal Structural Differences
Biopolymers, 2026, 117(2), e70084.
https://doi.org/10.1002/bip.70084
N-to-C peptide elongation by ammonia-Ugi reaction: synthesis of potent self-assembling elastin-like short peptides.
Org. Biomol. Chem., 2026, 24, 587-591.
https://doi.org/10.1039/D5OB01834J
Azobenzene-Modified Temperature-Responsive Short Elastin-like Peptides for Photo-Controlled Phase Transition
ACS Synth. Biol. 2025, 14, 8, 2999–3012.
https://doi.org/10.1021/acssynbio.4c00889
Development of the Efficient Preparation Method for Thermoresponsive Elastin-Like Peptides Using Liquid-Phase Synthesis Combined with Fragment Condensation Strategy. In: Hussein, W.M., Skwarczynski, M. (eds) Peptide Synthesis. Methods in Molecular Biology, vol 2931. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4562-8_9
Recent Advances and Applications in Self-Assembling Short-Chain Elastin-Like Peptide Analogs. in Uversky, Vladimir N., and Munishwar Nath Gupta, eds. Repeat Amino Acid Sequences in Proteins: Biochemical and Medical Consequences. CRC Press, 2025.: 123-146
Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention
ACS Medicinal Chemistry Letters, 16(1), 144–148 (2025)
https://pubs.acs.org/doi/full/10.1021/acsmdchemlett.4c00503
Straightforward Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives Using Readily Accessible Building Blocks
Synlett 2025; 36(17): 2671-2683
DOI: 10.1055/a-2508-4824
The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins X
Plos One 19 (10), e0312276 (2024)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312276
Exploring LCST-and UCST-like Behavior of Branched Molecules Bearing Repeat Units of Elastin-like Peptides as Side Components
Biomacromolecules 25 (11), 7156-7166 (2024) https://pubs.acs.org/doi/full/10.1021/acs.biomac.4c00751
Ammonium carboxylates in the ammonia-Ugi reaction: one-pot synthesis of α, α-disubstituted amino acid derivatives including unnatural dipeptides
Organic & Biomolecular Chemistry 22 (34), 6999-7005 (2024) https://pubs.rsc.org/en/content/articlehtml/2024/ob/d4ob00924j
Enhancement of Aggregate Formation Through Aromatic Compound Adsorption in Elastin-like Peptide (FPGVG)5 Analogs
Biomacromolecules 2023, 24, 11, 5265-5276 (Article)
Subscribed Publication Date (Web):October 22, 2023
DOI: 10.1021/acs.biomac.3c00779
薬史を題材とした学部生向けの英語ライティング教材の開発
薬史学雑誌 58 (2), 100-109, 2023-12-31
Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach
Biological and Pharmaceutical Bulletin 46(10), 1412, (2023)
https://doi.org/10.1248/bpb.b23-00224
Determining the Sequence Dependency of Self-Assembly of Elastin-Like Peptides Using Short Peptide Analogues with Shuffled Repetitive Sequences
Biochemistry, 62(17), 2559 (2023)
https://doi.org/10.1021/acs.biochem.3c00146
Development of the efficient preparation method for thermoresponsive elastin-like peptides using liquid-phase synthesis combined with fragment condensation strategy
Journal of Peptide Science, June (2023).
https://doi.org/10.1002/psc.3528
High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways
Heliyon, Volume 9, Issue 1, e13003, January (2023).
https://doi.org/10.1016/j.heliyon.2023.e13003
Development of truncated elastin-like peptide analogues with improved temperature-response and self-assembling properties
Scientific Reports, volume12, Article number: 19414 (2022).
https://doi.org/10.1038/s41598-022-23940-0
Branched short elastin-like peptides with temperature responsiveness obtained by EDTA-mediated multimerization
Journal of Peptide Science, e3449, (2022)
Product hybrids by the Ugi reaction in complex media conatining
Scientific Reports, volume12, Article number: 15568 (2022).
https://doi.org/10.1038/s41598-022-19579-6
Flexible customization of the self-assembling abilities of short elastin-like peptide Fn analogs by substituting N-terminal amino acids
Biopolymers, e23521, (2022)
Metal ion scavenging activity of elastin-like peptide analogues containing a cadmium ion binding sequence
Scientific Reports, volume12, Article number: 1861 (2022)
https://doi.org/10.1038/s41598-022-05695-w
Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation
Bioorganic & Medicinal Chemistry, 2021 51, 116498.
https://doi.org/10.1016/j.bmc.2021.116498
Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β
J. Biol. Chem., 2021 297(5) 101173.
https://doi.org/10.1016/j.jbc.2021.101173
Simple Regulation of the Self-Assembling Ability by Multimerization of Elastin-Derived Peptide (FPGVG)n Using Nitrilotriacetic Acid as a Building Block
ACS Omega 2021, 6, 8, 5705–5716
https://doi.org/10.1021/acsomega.0c06140
Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
PLOS ONE, 2021, https://doi.org/10.1371/journal.pone.0246583
Mechanistic insights into a DMSO-perturbing inhibitory assay of hyaluronidase
Biochemistry, 2020, 59, 40, 3879–388.
https://doi.org/10.1021/acs.biochem.0c00594
Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ
Chem. Res. Toxicol. 2020, 33, 4, pp889-902. https://doi.org/10.1021/acs.chemrestox.9b00379.
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities
Bioorganic & Medicinal Chemistry, 2020 Feb 1;28(3):115274.
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay
Bioorganic & Medicinal Chemistry Letters, 2020 Jan 15;30(2):126815.
Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors
Toxicology and Applied Pharmacology, 8, 15 2019, 377, 114610.
DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.9b00093, 2019, 10, 6, pp 923-928, 2019.06
Importance of Receptor Conformations in Docking Calculation-Based Risk Assessment for Endocrine Disruptors against Estrogen Receptor α, ACS Omega, 10.1021/acsomega.9b000, 502019, 4 (4), pp 6620–6629, 2019.04.
Enhancement of self-aggregation properties of linear elastin-derived short peptides by simple cyclization strong self-aggregation properties of cyclo[FPGVG]n, consisting only of natural amino acids, Biomacromolecules, 10.1021/acs.biomac.8b00353, 19, 8, 3201-3211, 2018.02
Stepwise Mechanism of Temperature-Dependent Coacervation of the Elastin-like Peptide Analogue Dimer, (C(WPGVG)3)2, Biochemistry, 10.1021/acs.biochem.7b01144, 57, 10, 1582-1590, 2018.03.
Angiotensin I Converting Enzyme-inhibiting Peptides Purified from Elastase-degraded Elastin Prepared from Pig Aorta, Current Enzyme Inhibition, 10.2174/1573408013666170912113121, 14, 67-74, 2018.03.
Multifunctional biological activities of water extract of housefly larvae (Musca domestica), PharmaNutrition, 10.1016/j.phanu.2017.09.001, 5, 4, 119-126, 2017.12
Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects, JOURNAL OF COSMETIC SCIENCE, 10.1002/psc.2837, 68, 1-13, 2017.01.
Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom, Toxicon, 10.1016/j.toxicon.2016.09.013, 122, 31-38, 2016.11.
Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning, Biochemistry, 10.1021/acs.biochem.6b00139, 55, 21, 2927-2935, 2016.05.
Dimerization effects on coacervation property of an elastin-derived synthetic peptide (FPGVG)5, Journal of Peptide Science, 10.1002/psc.2876, 22, 236-243, 2016.03.
Development of short and highly potent self-assembling elastin-derived pentapeptide repeats containing aromatic amino acid residues, Journal of Peptide Science, 10.1002/psc.2837, 22, 1, 36-42, 2016.01.
Design of Phenylalanine-Containing Elastin-Derived Peptides Exhibiting Highly Potent Self-Assembling Capability , Protein & Peptide Letters, 10.2174/092986652210150821170703, 22, 10, 939-939, 2015.08.
Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
PLOS ONE, 2021, https://doi.org/10.1371/journal.pone.0246583
Mechanistic insights into a DMSO-perturbing inhibitory assay of hyaluronidase
Biochemistry, 2020, 59, 40, 3879–388.
https://doi.org/10.1021/acs.biochem.0c00594
Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ
Chem. Res. Toxicol. 2020, 33, 4, pp889-902. https://doi.org/10.1021/acs.chemrestox.9b00379.
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities
Bioorganic & Medicinal Chemistry, 2020 Feb 1;28(3):115274.
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay
Bioorganic & Medicinal Chemistry Letters, 2020 Jan 15;30(2):126815.
Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors
Toxicology and Applied Pharmacology, 8, 15 2019, 377, 114610.
DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.9b00093, 2019, 10, 6, pp 923-928, 2019.06
Importance of Receptor Conformations in Docking Calculation-Based Risk Assessment for Endocrine Disruptors against Estrogen Receptor α, ACS Omega, 10.1021/acsomega.9b000, 502019, 4 (4), pp 6620–6629, 2019.04.
Enhancement of self-aggregation properties of linear elastin-derived short peptides by simple cyclization strong self-aggregation properties of cyclo[FPGVG]n, consisting only of natural amino acids, Biomacromolecules, 10.1021/acs.biomac.8b00353, 19, 8, 3201-3211, 2018.02
Stepwise Mechanism of Temperature-Dependent Coacervation of the Elastin-like Peptide Analogue Dimer, (C(WPGVG)3)2, Biochemistry, 10.1021/acs.biochem.7b01144, 57, 10, 1582-1590, 2018.03.
Angiotensin I Converting Enzyme-inhibiting Peptides Purified from Elastase-degraded Elastin Prepared from Pig Aorta, Current Enzyme Inhibition, 10.2174/1573408013666170912113121, 14, 67-74, 2018.03.
Multifunctional biological activities of water extract of housefly larvae (Musca domestica), PharmaNutrition, 10.1016/j.phanu.2017.09.001, 5, 4, 119-126, 2017.12
Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects, JOURNAL OF COSMETIC SCIENCE, 10.1002/psc.2837, 68, 1-13, 2017.01.
Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom, Toxicon, 10.1016/j.toxicon.2016.09.013, 122, 31-38, 2016.11.
Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning, Biochemistry, 10.1021/acs.biochem.6b00139, 55, 21, 2927-2935, 2016.05.
Dimerization effects on coacervation property of an elastin-derived synthetic peptide (FPGVG)5, Journal of Peptide Science, 10.1002/psc.2876, 22, 236-243, 2016.03.
Development of short and highly potent self-assembling elastin-derived pentapeptide repeats containing aromatic amino acid residues, Journal of Peptide Science, 10.1002/psc.2837, 22, 1, 36-42, 2016.01.
Design of Phenylalanine-Containing Elastin-Derived Peptides Exhibiting Highly Potent Self-Assembling Capability , Protein & Peptide Letters, 10.2174/092986652210150821170703, 22, 10, 939-939, 2015.08.